Description

3-(Difluoromethyl)Oxetane-3-Carboxylic Acid is a high-value, multifunctional oxetane building block characterized by its carboxylic acid group and difluoromethyl substituent. This compound matters for its unique reactivity profile, enabling the synthesis of complex molecules with enhanced physicochemical properties. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, where the difluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for synthesizing specialty polymers with tailored properties like chemical resistance or specific dielectric constants.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel chelating ligands or metal-organic frameworks (MOFs) for catalytic applications.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and incorporating fluorine atoms into complex molecular architectures to modulate lipophilicity and binding affinity.
• Peptidomimetics & Bioisosteres: The oxetane ring can act as a bioisostere for carbonyl or gem-dimethyl groups, making this acid useful in designing peptide mimics and conformationally restricted analogs.

Basic Information

Product Name	3-(Difluoromethyl)Oxetane-3-Carboxylic Acid
CAS No.	1782290-73-6
Molecular Formula	C5H6F2O3
Molecular Weight	152.10 g/mol
Synonyms	3-(Difluoromethyl)-3-oxetanecarboxylic acid; Oxetane-3-carboxylic acid, 3-(difluoromethyl)-; 3-Carboxy-3-(difluoromethyl)oxetane; 3-Oxetanecarboxylic acid, 3-(difluoromethyl)-; DFMOA (abbreviation)
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Oxetane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, appropriate chemical-resistant materials should be used for handling and storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.