Description

Ethanone, 1-(2-Chloro-3,4-Difluorophenyl)- is a high-purity, halogenated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce a specific difluorinated and chlorinated phenyl moiety into their target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the difluoro and chloro substituents can enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty polymers and liquid crystal materials that require specific halogenated aromatic components.
• Organic Electronic Materials: Acts as a building block for electron-deficient aromatic units used in organic semiconductors and OLED materials.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, or other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	Ethanone, 1-(2-Chloro-3,4-Difluorophenyl)-
CAS No.	1780183-09-6
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2-Chloro-3,4-difluoroacetophenone; 1-(2-Chloro-3,4-difluorophenyl)ethanone; 2'-Chloro-3',4'-difluoroacetophenone; 2-Chloro-3,4-difluorophenyl methyl ketone; Acetophenone, 2-chloro-3,4-difluoro-; 1-Acetyl-2-chloro-3,4-difluorobenzene; (2-Chloro-3,4-difluorophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(2-Chloro-3,4-Difluorophenyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.