Description

(4,4-Difluorooxolan-3-Yl)Methanol is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the introduction of a difluorinated tetrahydrofuran scaffold, which is crucial for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating a difluorinated oxygen heterocycle into potential drug candidates, particularly in medicinal chemistry programs targeting CNS, antiviral, or anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluoro motif can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, leveraging the stereogenic center and fluorine atoms.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty chemicals with unique surface properties, such as low surface energy or enhanced chemical resistance.
• Fluorine Chemistry Exploration: Acts as a valuable substrate for studying novel fluorination reactions or as a building block for more complex fluorinated architectures.

Basic Information

Product Name	(4,4-Difluorooxolan-3-Yl)Methanol
CAS No.	1780169-27-8
Molecular Formula	C5H8F2O2
Molecular Weight	138.11 g/mol
Synonyms	(4,4-Difluorotetrahydrofuran-3-yl)methanol; 3-(Hydroxymethyl)-4,4-difluorotetrahydrofuran; 4,4-Difluorooxolan-3-ylmethanol; 4,4-Difluorotetrahydro-3-furanmethanol; (4,4-Difluorooxolan-3-yl)methanol; 3-Hydroxymethyl-4,4-difluorotetrahydrofuran
EINECS	Contact for details

Quality Control

Our (4,4-Difluorooxolan-3-Yl)Methanol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.