Description

8,8-Difluoro-3-Azabicyclo[3.2.1]Octane Hydrochloride is a high-value, structurally complex bicyclic amine hydrochloride salt featuring two strategically placed fluorine atoms. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialized fluorinated scaffolds for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Building Block: Used in hit-to-lead optimization and library synthesis to explore structure-activity relationships (SAR), leveraging the fluorine atoms for improved metabolic stability and bioavailability.
• Agrochemical Research: Serves as a sophisticated synthon for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: The constrained bicyclic structure makes it a candidate for developing chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probe Synthesis: Utilized in creating molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Potential monomer or additive for creating specialty polymers with unique thermal or surface properties.

Basic Information

Product Name	8,8-Difluoro-3-Azabicyclo[3.2.1]Octane Hydrochloride
CAS No.	1779942-70-9
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	8,8-Difluoro-3-azabicyclo[3.2.1]octane HCl; 3-Azabicyclo[3.2.1]octane, 8,8-difluoro-, hydrochloride; 8,8-Difluoro-3-azabicyclo[3.2.1]octane hydrochloride; 8,8-Difluoro-3-azoniabicyclo[3.2.1]octane chloride; Tropane, 8,8-difluoro-, hydrochloride; Difluorotropane hydrochloride
EINECS	Contact for details

Quality Control

Our 8,8-Difluoro-3-Azabicyclo[3.2.1]Octane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.