Description

4,4-Difluoro-1-Methylpyrrolidine-3-Carboxylic Acid is a high-purity, fluorinated pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group and two fluorine atoms on the pyrrolidine ring, makes it a valuable scaffold for modulating the physicochemical properties of target molecules. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its incorporation can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the difluoropyrrolidine moiety can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Incorporated into molecular probes and tags for studying biological processes and protein interactions.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored properties.

Basic Information

Product Name	4,4-Difluoro-1-Methylpyrrolidine-3-Carboxylic Acid
CAS No.	1779842-14-6
Molecular Formula	C7H9F2NO2
Molecular Weight	177.15 g/mol
Synonyms	1-Methyl-4,4-difluoropyrrolidine-3-carboxylic acid; 4,4-Difluoro-1-methyl-3-pyrrolidinecarboxylic acid; 3-Carboxy-1-methyl-4,4-difluoropyrrolidine; 4,4-Difluoro-1-methylpyrrolidine-3-carboxylic acid; 1-Methyl-4,4-difluoro-3-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 4,4-Difluoro-1-Methylpyrrolidine-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.