Description

1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,5-Dihydro-1H-Pyrrole is a versatile and high-value organoboron building block, specifically a protected pyrrole boronic ester. This compound is essential for modern synthetic chemistry, enabling the precise construction of complex molecular architectures through cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-couplings for constructing C-C bonds in drug discovery and development, particularly for creating heterocyclic cores prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require complex, boron-containing heterocyclic structures.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as conductive polymers, OLED (Organic Light-Emitting Diode) components, and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of bioconjugates and molecular probes for studying biological processes and target engagement.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and catalysis research within university and corporate laboratories.
• Scale-up Process Chemistry: Suitable for optimization and scale-up from milligram to kilogram quantities for pre-clinical and early-phase clinical manufacturing.

Basic Information

Product Name	1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,5-Dihydro-1H-Pyrrole
CAS No.	1779540-37-2
Molecular Formula	C11H20BNO2
Molecular Weight	209.09 g/mol
Synonyms	1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole; 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydro-pyrrole; 1-Methyl-3-(pinacolboryl)-2,5-dihydro-1H-pyrrole; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-2,5-dihydro-1H-pyrrole; 1-Methyl-3-pinacolatoboryl-2,5-dihydro-1H-pyrrole; 1-Methyl-3-(pinacolatoboryl)-2,5-dihydro-1H-pyrrole; N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,5-Dihydro-1H-Pyrrole adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR (1H, 13C, 11B), HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant regulatory frameworks for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, this material should be handled and stored under an inert atmosphere (argon or nitrogen) in a desiccated environment to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.