Description

(1R,5S)-8-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-8-Azabicyclo[3.2.1]Oct-2-Ene is a sophisticated, chiral boronic ester derivative of the tropane alkaloid scaffold, serving as a critical advanced pharmaceutical intermediate for modern drug discovery. Its value lies in its role as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex, drug-like molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel central nervous system (CNS) active agents and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Agrochemical Research: Used in the development of new, more selective pesticides and herbicides through structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological pathways and protein interactions.
• Catalyst Ligand Synthesis: Serves as a precursor for novel chiral ligands used in asymmetric catalysis.
• Material Science: Potential monomer or additive for creating specialty polymers with unique electronic or structural properties.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and complex molecule construction in research laboratories.

Basic Information

Item	Details
Product Name	(1R,5S)-8-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-8-Azabicyclo[3.2.1]Oct-2-Ene
CAS No.	1779539-89-7
Molecular Formula	C16H28BNO2
Molecular Weight	277.21 g/mol
Synonyms	(1R,5S)-8-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene; (1R,5S)-Tropane-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene (enantiomer); 8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, (1R,5S)-; Chiral Tropane Boronate Ester; (1R,5S)-3-BPin-tropane
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We support development from milligram to kilogram scale with GMP-ready documentation and can tailor specifications to meet the exacting requirements of your project.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.