Description

4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Tetrahydro-2H-Thiopyran 1,1-Dioxide is a high-purity, advanced pharmaceutical intermediate featuring a pyrazole core linked to a tetrahydrothiopyran dioxide moiety via a pinacol boronate ester. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key boron-containing reagent for constructing carbon-carbon bonds in the synthesis of complex heterocyclic compounds.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug candidates.
• Agrochemical Synthesis: Employed in the development of novel pesticides and herbicides with specific biological activity.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysts.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Tetrahydro-2H-Thiopyran 1,1-Dioxide
CAS No.	1778666-13-9
Molecular Formula	C14H23BN2O4S
Molecular Weight	326.22 g/mol
Synonyms	4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide; 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]thiacyclohexane 1,1-dioxide; Tetrahydro-2H-thiopyran-4-yl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate 1,1-dioxide (tautomeric form); 4-(4-Boronic acid pinacol ester-1H-pyrazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide; CAS 1778666-13-9; Pyrazole boronic ester derivative; Thiopyran dioxide pyrazole boronate.
EINECS	Contact for details

Quality Control

Our 4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Tetrahydro-2H-Thiopyran 1,1-Dioxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.