Description

2,2-Difluoro-1-o-Tolyl-Cyclopropanecarboxylic Acid is a high-value, fluorinated cyclopropane derivative, a key structural motif prized for its ability to modulate the physicochemical and metabolic properties of target molecules. Its primary commercial value lies in its role as a sophisticated pharmaceutical intermediate and agrochemical building block, enabling the synthesis of novel compounds with enhanced biological activity and stability. This compound is essential for R&D and production teams in the life sciences sector seeking to incorporate difluorocyclopropane chemistry into their development pipelines.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorocyclopropane unit can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced materials with unique fluorinated properties.
• Organic Synthesis & Catalysis: Employed in academic and industrial research as a versatile reagent for constructing complex, fluorinated organic molecules and exploring new catalytic cycles.
• Ligand & Catalyst Development: The carboxylic acid functionality and rigid cyclopropane core make it a candidate for designing novel chiral ligands and organocatalysts.

Basic Information

Product Name	2,2-Difluoro-1-o-Tolyl-Cyclopropanecarboxylic Acid
CAS No.	1774902-99-6
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	1-(2-Methylphenyl)-2,2-difluorocyclopropane-1-carboxylic Acid; o-Tolyl-2,2-difluorocyclopropanecarboxylic Acid; 2,2-Difluoro-1-(2-methylphenyl)cyclopropanecarboxylic Acid; 2-Methyl-α,α-difluorocyclopropaneacetic Acid (benzylic isomer); DFCPC Acid (abbrev.)
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1-o-Tolyl-Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.