Description

Naphthalene-1-Boronic Acid Mida Ester is a specialized, protected boronic acid derivative designed for advanced synthetic applications. This compound is crucial for enabling robust, iterative cross-coupling reactions, offering superior stability and handling compared to its free boronic acid counterpart. It is an essential building block for researchers and process chemists in pharmaceutical development and agrochemical synthesis who require reliable, high-purity intermediates for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling for constructing biaryl motifs in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific naphthalene-based architectures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Complex Molecule Construction: Enables iterative, multi-step synthesis in medicinal chemistry due to the MIDA ester's protective stability.
• Ligand and Catalyst Development: Used in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	Naphthalene-1-Boronic Acid Mida Ester
CAS No.	1771757-13-1
Molecular Formula	C₁₅H₁₅BN₂O₄
Molecular Weight	298.11 g/mol
Synonyms	1-Naphthaleneboronic Acid MIDA Ester; N-(1-Naphthylboronic acid)-N-methyliminodiacetic Acid Ester; 1-NaphthylMIDA Boronate; B-(1-Naphthyl)-N-methyliminodiacetic Acid Boronate Ester; MIDA Boronate of 1-Naphthaleneboronic Acid; 1-Naphthylboronic Acid MIDA Ester; (1-Naphthyl)-MIDA-Boronate; N-Methyliminodiacetic Acid (1-Naphthyl)boronate
EINECS	Contact for details

Quality Control

Our Naphthalene-1-Boronic Acid Mida Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.