Description

1(2H)-Isoquinolinone, 2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, organoboron-containing heterocyclic building block, essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, leveraging the isoquinolinone scaffold for bioactivity.
• Material Science Research: Building block for organic electronic materials, including OLEDs and organic semiconductors, where the boronic ester group facilitates polymerization.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Catalyst Ligand Development: The heterocyclic structure can be modified to create novel ligands for transition metal catalysis.
• Academic & R&D Laboratories: Fundamental research tool in synthetic organic chemistry for methodology development and exploring new reaction pathways.

Basic Information

Product Name	1(2H)-Isoquinolinone, 2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1706749-69-0
Molecular Formula	C₁₆H₂₂BNO₃
Molecular Weight	287.17 g/mol
Synonyms	2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1,2-dihydroisoquinolin-1-one; 2-Methyl-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1(2H)-isoquinolinone; 2-Methyl-1-oxo-1,2-dihydroisoquinoline-6-boronic acid pinacol ester; 6-BPin-2-methyl-1-isoquinolone; (2-Methyl-1-oxo-1,2-dihydroisoquinolin-6-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1(2H)-Isoquinolinone, 2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.