Description

2',3'-Difluoro-5'-Methoxy-4'-Methylacetophenone is a high-purity fluorinated acetophenone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique substitution pattern, which provides a versatile scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on novel active ingredients, where precise molecular architecture is paramount for achieving desired biological activity and selectivity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in therapeutic areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro and methoxy groups can influence target binding and environmental persistence.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to introduce complex aryl ketone functionalities into target molecules.
• Academic & Industrial R&D: Serves as a standard or starting material in methodological studies and process chemistry optimization within university and corporate laboratories.

Basic Information

Item	Details
Product Name	2',3'-Difluoro-5'-Methoxy-4'-Methylacetophenone
CAS No.	1706436-19-2
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	1-(2,3-Difluoro-5-methoxy-4-methylphenyl)ethan-1-one; 2,3-Difluoro-5-methoxy-4-methylacetophenone; 2,3-Difluoro-5-methoxy-4-methylphenyl methyl ketone; 2',3'-Difluoro-5'-methoxy-4'-methylacetophenone; 2,3-Difluoro-5-methoxy-p-tolyl methyl ketone; 2,3-Difluoro-5-methoxy-4-methyl-1-acetylbenzene; 2,3-Difluoro-5-methoxy-4-methylphenylacetone; 2,3-Difluoro-5-methoxy-4-methylacetophenone (CAS 1706436-19-2)
EINECS	Contact for details

Quality Control

Our 2',3'-Difluoro-5'-Methoxy-4'-Methylacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.