Description

4-Iodo-1-Trifluoromethyl-1H-Pyrazole is a high-value, halogenated pyrazole derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining an iodine substituent with a trifluoromethyl group on the pyrazole ring, makes it a versatile intermediate for introducing these functional motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl and iodine groups.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials where specific halogen and fluorine content is required.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl and conjugated systems.
• Chemical Biology: Employed as a probe or tag in biochemical research due to the reactivity of the iodine moiety for further functionalization.
• Fluorine Chemistry: A valuable reagent for introducing the trifluoromethyl group into heterocyclic scaffolds, a common strategy in modern lead optimization.

Basic Information

Product Name	4-Iodo-1-Trifluoromethyl-1H-Pyrazole
CAS No.	1706433-09-1
Molecular Formula	C4H2F3IN2
Molecular Weight	261.97 g/mol
Synonyms	1-(Trifluoromethyl)-4-iodo-1H-pyrazole; 4-Iodo-1-(trifluoromethyl)-1H-pyrazole; 1H-Pyrazole, 4-iodo-1-(trifluoromethyl)-; 4-Iodo-1-trifluoromethylpyrazole; 1706433-09-1; 4-Iodo-1-trifluoromethyl-1H-pyrazole; 4-Iodo-1-trifluoromethylpyrazole
EINECS	Contact for details

Quality Control

Our 4-Iodo-1-Trifluoromethyl-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep the container sealed to minimize exposure to moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.