Description

Potassium Trifluoro(3-Oxo-3-((2-(Trifluoromethoxy)Phenyl)Amino)Propyl)Borate is a specialized organoboron reagent featuring a unique trifluoroborate moiety and a trifluoromethoxy-substituted anilide linker. This compound matters as a high-value building block for advanced organic synthesis, offering enhanced stability and reactivity for cross-coupling reactions compared to traditional boronic acids. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for drug discovery, particularly in creating compounds with improved metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable organotrifluoroborate reagent for palladium-catalyzed carbon-carbon bond formation, crucial for constructing biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group confers desirable biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Fluorine Chemistry: Acts as a valuable synthon for introducing fluorine and trifluoromethoxy groups into target molecules, a common strategy in modern medicinal chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations that require high-purity, specialized building blocks for client projects.

Basic Information

Item	Detail
Product Name	Potassium Trifluoro(3-Oxo-3-((2-(Trifluoromethoxy)Phenyl)Amino)Propyl)Borate
CAS No.	1705578-34-2
Molecular Formula	C10H9BF6KNO3
Molecular Weight	358.09 g/mol
Synonyms	Potassium (3-Oxo-3-((2-(trifluoromethoxy)phenyl)amino)propyl)trifluoroborate; Potassium 3-((2-(Trifluoromethoxy)phenyl)amino)-3-oxopropyltrifluoroborate; N-(2-(Trifluoromethoxy)phenyl)-3-oxo-3-(potassium trifluoroboranyl)propanamide; Trifluoro(3-oxo-3-((2-(trifluoromethoxy)phenyl)amino)propyl)boron Potassium Salt; Potassium Organotrifluoroborate Reagent; Potassium Trifluoroborate Ester Amide; KTFB Reagent
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro(3-Oxo-3-((2-(Trifluoromethoxy)Phenyl)Amino)Propyl)Borate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B), HPLC, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) in a dry environment to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.