Description

4-Hydroxy-n-(3-(4,4,5-Trimethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is of significant value in modern medicinal chemistry, primarily serving as a crucial building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is essential for research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel small-molecule therapeutics, kinase inhibitors, and other targeted agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific enzymes or receptors.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety makes this compound an ideal reagent for constructing biaryl and heterobiaryl structures, a cornerstone reaction in drug discovery.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic entities with improved potency and selectivity.
• API Development: Integral to the process development and scale-up stages for new active pharmaceutical ingredients, ensuring reliable and reproducible synthesis.
• Bioconjugation & Probe Synthesis: Can be utilized in the development of chemical probes for biological target identification and validation within cellular systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client drug programs.

Basic Information

Product Name	4-Hydroxy-n-(3-(4,4,5-Trimethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide
CAS No.	1704081-94-6
Molecular Formula	C19H29BN2O4
Molecular Weight	360.26 g/mol
Synonyms	4-Hydroxy-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxamide; 1-Piperidinecarboxamide, 4-hydroxy-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-Hydroxy-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxamide; PINACOL [3-(4-HYDROXY-1-PIPERIDINECARBOXAMIDO)PHENYL]BORONATE; [3-[(4-Hydroxypiperidine-1-carbonyl)amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-n-(3-(4,4,5-Trimethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.