Description

2-Morpholino-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those containing indole or morpholine motifs.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety makes it an essential reagent for forming carbon-carbon bonds between aromatic rings under mild conditions.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes from milligram to kilogram scale for clinical trial material production.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Agrochemical Research: Potential application as an intermediate in the development of novel crop protection agents with complex heterocyclic structures.

Basic Information

Item	Details
Product Name	2-Morpholino-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone
CAS No.	1704067-45-7
Molecular Formula	C21H29BN2O4
Molecular Weight	384.28 g/mol
Synonyms	1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-1-yl]-2-morpholinoethanone; 2-Morpholino-1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-morpholinoacetyl)indoline; CAS 1704067-45-7; Boronic acid, B-[1-(2-morpholinoacetyl)-2,3-dihydro-1H-indol-5-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Morpholino-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its moisture-sensitive and easily oxidized nature, the container should be opened only under anhydrous conditions and resealed immediately after use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.