Description

2-Chloro-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is essential for modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, which are fundamental for constructing complex molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates, especially those containing indoline or related heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile coupling partner to form carbon-carbon bonds, enabling the construction of biaryl and other conjugated systems central to many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics, where precise molecular structure is key.
• Chemical Biology & Medicinal Chemistry: Utilized in the design and synthesis of molecular probes and tool compounds for target validation and biochemical pathway studies.

Basic Information

Item	Detail
Product Name	2-Chloro-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone
CAS No.	1704067-44-6
Molecular Formula	C17H21BClNO3
Molecular Weight	333.62 g/mol
Synonyms	1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-1-yl)-2-chloroethanone; 2-Chloro-1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-1-yl]ethanone; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-(2-chloroacetyl); 2-Chloro-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-1-yl)ethanone; 1-(5-(Pinacolatoboryl)indolin-1-yl)-2-chloroethanone; 5-Pinacolatoboryl-1-(2-chloroacetyl)indoline
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.