Description

1-Bromo-3-Ethynyl-2-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block. This compound is valued for its unique molecular architecture, featuring reactive bromo, fluoro, and ethynyl groups, which enable precise and diverse chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing complex aromatic cores.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides that require halogenated aromatic structures.
• Material Science: Serves as a precursor for advanced polymers, liquid crystals, and organic electronic materials due to its ethynyl group for cross-coupling reactions.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Suzuki, and Buchwald-Hartwig amination reactions to introduce the ethynylbenzene moiety.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating molecular libraries.
• Fluorine Chemistry: The presence of both fluorine and bromine makes it a valuable compound for studying structure-activity relationships and metabolic stability in drug design.

Basic Information

Product Name	1-Bromo-3-Ethynyl-2-Fluorobenzene
CAS No.	1701568-15-1
Molecular Formula	C8H4BrF
Molecular Weight	199.02 g/mol
Synonyms	2-Fluoro-3-bromoethynylbenzene; 3-Bromo-2-fluoroethynylbenzene; 1-Bromo-2-fluoro-3-ethynylbenzene; 2-Fluoro-1-bromo-3-ethynylbenzene; 3-Ethynyl-2-fluoro-1-bromobenzene; (3-Bromo-2-fluorophenyl)acetylene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Ethynyl-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.