Description

(5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-Yl)Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. Its core value proposition lies in enabling efficient and selective carbon-carbon bond formation, a critical step in constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, catalyst development, and material science.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Used in the synthesis of compound libraries for high-throughput screening and the development of novel drug candidates, particularly for CNS and oncology targets.
• Agrochemical Intermediate: Employed in the research and synthesis of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Catalyst Ligand Synthesis: Utilized to construct sophisticated ligand frameworks for transition metal catalysis.
• Chemical Biology Probes: Acts as a handle for bioconjugation and the development of activity-based probes for studying biological systems.

Basic Information

Product Name	(5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-Yl)Boronic Acid Pinacol Ester
CAS No.	1701460-54-9
Molecular Formula	C15H23BN2O2
Molecular Weight	274.17 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydro-1,8-naphthyridine; 5,6,7,8-Tetrahydro-1,8-naphthyridine-3-boronic acid pinacol ester; 2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydro[1,8]naphthyridine
EINECS	Contact for details

Quality Control

Our (5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance in sensitive coupling reactions. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.