Description

2-(3,4-Dichloro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel active ingredients and functional molecules. The CAS number for this compound is 1701449-89-9.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor for constructing complex drug candidates, particularly those containing substituted biphenyl or heteroaryl scaffolds central to many therapeutic agents.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the dichloro-methoxyphenyl moiety.
• Material Science & OLED Development: Serves as a building block for creating advanced organic electronic materials, including charge-transport layers and emissive materials for OLED displays and lighting.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology & Probe Development: Useful for creating molecular probes and tagged compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke organic compounds for client projects.

Basic Information

Product Name	2-(3,4-Dichloro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1701449-89-9
Molecular Formula	C₁₃H₁₇BCl₂O₃
Molecular Weight	303.99 g/mol
Synonyms	(3,4-Dichloro-5-methoxyphenyl)boronic acid pinacol ester; 3,4-Dichloro-5-methoxybenzeneboronic acid pinacol ester; 2-(3,4-Dichloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3,4-Dichloro-5-methoxyphenyl)BPin; Pinacol (3,4-dichloro-5-methoxyphenyl)boronate; 1701449-89-9; Boronic acid, B-(3,4-dichloro-5-methoxyphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-(3,4-Dichloro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and GC to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high reliability, from early-stage R&D to scale-up under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.