Description

5-Chloro-4-Fluoro-2-Hydroxybenzonitrile is a high-purity halogenated benzonitrile derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its unique molecular structure, featuring chloro, fluoro, and hydroxy substituents, enables precise functionalization for developing novel active compounds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used as a building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated aromatic core.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated and chlorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex, multi-substituted benzene rings into target molecules.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for high-throughput screening.
• Dye & Pigment Intermediate: Acts as a precursor in the manufacture of specialized halogenated dyes and pigments, where the substituents alter color fastness and spectral properties.

Basic Information

Product Name	5-Chloro-4-Fluoro-2-Hydroxybenzonitrile
CAS No.	1691192-63-8
Molecular Formula	C7H3ClFNO
Molecular Weight	171.56 g/mol
Synonyms	2-Hydroxy-5-chloro-4-fluorobenzonitrile; 4-Fluoro-5-chloro-2-hydroxybenzonitrile; 5-Chloro-4-fluoro-2-hydroxybenzonitrile; 2-Cyano-4-chloro-5-fluorophenol; Benzonitrile, 5-chloro-4-fluoro-2-hydroxy-; 4-Chloro-5-fluoro-2-hydroxybenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Fluoro-2-Hydroxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.