Description

4,4,5,5-Tetramethyl-2-(2,3,5-trifluorophenyl)-1,3,2-dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient and selective cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to constructing complex molecular architectures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, including potential kinase inhibitors, antiviral agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the trifluorophenyl moiety for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating fluorinated organic electronic materials, such as those used in OLEDs, semiconductors, and liquid crystals.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile coupling partner (boron reagent) for forming carbon-carbon bonds between aryl/heteroaryl groups under palladium catalysis.
• Chemical Biology & Probe Development: Utilized in the synthesis of fluorinated molecular probes and tags for imaging, diagnostics, and studying biological mechanisms.
• Process Chemistry & Scale-Up: Suitable for route scouting and optimization from milligram to kilogram scale in GMP and non-GMP environments for commercial production.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2,3,5-trifluorophenyl)-1,3,2-dioxaborolane
CAS No.	1689529-59-6
Molecular Formula	C12H15BF3O2
Molecular Weight	250.06 g/mol
Synonyms	2-(2,3,5-Trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,3,5-Trifluorophenyl)boronic acid pinacol ester; 2,3,5-Trifluorophenylboronic acid pinacol ester; 2,3,5-Trifluorophenyl-Bpin; 2-(2,3,5-Trifluorophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; Pinacol (2,3,5-trifluorophenyl)boronate; 2,3,5-TrifluorophenylBPin
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(2,3,5-trifluorophenyl)-1,3,2-dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC analysis, to confirm identity, assay, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.