Description

3-Chloro-2-Methylphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this boronic ester, crucial for synthesizing biaryl structures found in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly those requiring substituted biphenyl or heterobiaryl motifs.
• Agrochemical Product Development: Employed in creating advanced herbicides, fungicides, and insecticides that incorporate chlorinated aromatic systems.
• Ligand and Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Material Science Research: Utilized in the development of organic electronic materials, such as those for OLEDs and semiconductors, where precise molecular structure is paramount.
• Chemical Biology Probes: Serves as a building block for creating molecular probes and tags used in biochemical research and diagnostics.

Basic Information

Item	Detail
Product Name	3-Chloro-2-Methylphenylboronic Acid Pinacol Ester
CAS No.	1688649-04-8
Molecular Formula	C₁₃H₁₈BClO₂
Molecular Weight	252.54 g/mol
Synonyms	3-Chloro-2-methylbenzeneboronic acid pinacol ester; (3-Chloro-2-methylphenyl)boronic acid pinacol ester; 2-Methyl-3-chlorophenylboronic acid pinacol ester; Pinacol (3-chloro-2-methylphenyl)boronate; 3-Chloro-o-tolylboronic acid pinacol ester; B-(3-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1688649-04-8
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Methylphenylboronic Acid Pinacol Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive cross-coupling applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant methods is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.