Description

1-{[5-Fluoro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine is a high-value, advanced pharmaceutical intermediate featuring a unique pyrrolidine-methyl-aryl boronic ester structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets. Its design facilitates efficient, late-stage functionalization in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for neurological and oncological applications.
• Suzuki-Miyaura Cross-Coupling Reactions: The tetramethyl dioxaborolane (pinacol boronic ester) group serves as a stable, reactive handle for forming carbon-carbon bonds with aryl halides.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• API Development: Integral to the process chemistry and scale-up stages for producing investigational new drugs.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or molecular probes for biochemical research.
• Agrochemical Research: May be employed in the discovery of new active ingredients with specific biological activity.

Basic Information

Product Name	1-{[5-Fluoro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine
CAS No.	1667753-41-4
Molecular Formula	C17H25BFNO2
Molecular Weight	305.20 g/mol
Synonyms	1-[(5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]pyrrolidine; 2-[2-[(Pyrrolidin-1-yl)methyl]-4-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-((5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl))pyrrolidine; (2-((Pyrrolidin-1-yl)methyl)-4-fluorophenyl)boronic acid pinacol ester; 5-Fluoro-2-(pyrrolidin-1-ylmethyl)phenylboronic acid pinacol ester; CAS 1667753-41-4
EINECS	Contact for details

Quality Control

Our 1-{[5-Fluoro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.