Description

n-(3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group. This compound is a critical building block in modern medicinal chemistry, enabling key carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. It is primarily utilized by research institutions and pharmaceutical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and other therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key reactant for constructing biaryl and heterobiaryl structures in drug discovery and development.
• Pharmaceutical Intermediate: Serves as a versatile building block for synthesizing complex molecules targeting various disease pathways.
• Organic Synthesis Research: Used in academic and industrial R&D labs for method development and creating novel chemical libraries.
• Ligand and Material Science Precursor: Potential starting material for synthesizing specialized ligands or organic electronic materials.
• Process Chemistry: Employed in scaling up synthetic routes for potential drug candidates during clinical development phases.

Basic Information

Product Name	n-(3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide
CAS No.	1667753-37-8
Molecular Formula	C13H19BClNO4S
Molecular Weight	331.62 g/mol
Synonyms	3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(methylsulfonyl)aniline; 2-(4-(N-Methanesulfonylamino)-2-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Methanesulfonamide, N-[3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 1667753-37-8; Boronic acid, B-[4-[(methylsulfonyl)amino]-2-chlorophenyl]-, 1,3,2-dioxaborolane deriv.
EINECS	Contact for details

Quality Control

Our production of n-(3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.