Description

3,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,5-Naphthyridine is a high-purity, advanced pharmaceutical intermediate featuring dual pinacol boronate ester functional groups. This compound is a critical building block in modern organic synthesis, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for the development of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile bis-boron reagent for the efficient synthesis of biaryl and heterobiaryl structures prevalent in drug discovery.
• Pharmaceutical Intermediate: A key precursor in the synthesis of potential active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex naphthyridine-based scaffolds.
• Materials Science & OLED Development: Employed in the creation of organic semiconductors, light-emitting diodes (OLEDs), and other electronic materials due to its rigid, conjugated structure.
• Chemical Biology & Probe Synthesis: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries in medicinal chemistry campaigns.

Basic Information

Item	Details
Product Name	3,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,5-Naphthyridine
CAS No.	1663470-21-0
Molecular Formula	C24H34B2N2O4
Molecular Weight	436.16 g/mol
Synonyms	1,5-Naphthyridine-3,7-diyldiboronic Acid Bis(pinacol) Ester; 3,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,5-Naphthyridine; 1,5-Naphthyridine-3,7-diboronic Acid Pinacol Ester; 3,7-Bis(Pinacolboranyl)-1,5-Naphthyridine; 3,7-Di(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,5-Naphthyridine; 3,7-Bis(4,4,5,5-Tetramethyl-2-dioxa-3-borinan-2-yl)-1,5-Naphthyridine; CAS 1663470-21-0
EINECS	Contact for details

Quality Control

Our 3,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,5-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.