Description

4-Methylthiazole-5-Boronic Acid Pinacol Ester is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in heterocyclic compound libraries.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science: Serves as a precursor for creating functionalized polymers and organic electronic materials.
• Cross-Coupling Reactions: Specifically designed as a stable reagent for palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds.
• Chemical Research: A valuable tool for medicinal chemists and process chemists in lead optimization and route scouting.
• Ligand Synthesis: Can be utilized in the preparation of novel ligands for catalysis.

Basic Information

Product Name	4-Methylthiazole-5-Boronic Acid Pinacol Ester
CAS No.	1662682-33-8
Molecular Formula	C₁₀H₁₆BNO₂S
Molecular Weight	225.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylthiazole; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4-Methylthiazol-5-ylboronic Acid Pinacol Ester; 4-Methyl-5-thiazoleboronic Acid Pinacol Ester; 4-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Pinacol 4-Methylthiazole-5-boronate
EINECS	Contact for details

Quality Control

Our 4-Methylthiazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 97%. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.