Description

1-(4-Pyridyl)Pyrazole-4-Boronic Acid Pinacol Ester is a high-purity, heterocyclic boronic ester building block crucial for modern synthetic chemistry. This compound matters as a key intermediate in the synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyrazole and pyridine pharmacophores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid functionality, enhancing stability and handling for efficient palladium-catalyzed carbon-carbon bond formation.
• Ligand and Catalyst Development: Utilized in the creation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	1-(4-Pyridyl)Pyrazole-4-Boronic Acid Pinacol Ester
CAS No.	1650548-69-8
Molecular Formula	C14H18BN3O2
Molecular Weight	271.13 g/mol
Synonyms	1-(Pyridin-4-yl)-1H-pyrazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-pyridinyl)-1H-pyrazole; 1-(4-Pyridinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(Pyridin-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(4-Pyridyl)-4-(pinacolboronato)pyrazole
EINECS	Contact for details

Quality Control

Our 1-(4-Pyridyl)Pyrazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.