Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-couplings for synthesizing novel drug candidates, especially in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used to create complex heterocyclic structures found in advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Building block for organic electronic materials, including OLEDs, OFETs, and conductive polymers, due to its fused dioxino-pyridine core.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate or tridentate ligands used in catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-fidelity boronic ester coupling partners.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine
CAS No.	1650548-67-6
Molecular Formula	C15H20BNO4
Molecular Weight	289.14 g/mol
Synonyms	2,3-Dihydro-[1,4]dioxino[2,3-b]pyridine-6-boronic acid pinacol ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro[1,4]dioxino[2,3-b]pyridine; [1,4]Dioxino[2,3-b]pyridine-6-boronic acid, 2,3-dihydro-, pinacol ester; 6-(Pinacolboryl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-[1,4]dioxino[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.