Description

2-(4-Fluorophenyl)Carbonylethylboronic Acid Pinacol Ester is a high-purity organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient formation of carbon-carbon bonds under mild conditions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex fluorinated aromatic scaffolds in active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating fluorinated biaryl structures found in various drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for palladium-catalyzed coupling with aryl/heteroaryl halides or triflates.
• Material Science Research: Used in the development of novel fluorinated organic electronic materials, such as OLEDs and semiconductors, where the fluorine moiety tunes electronic properties.
• Agrochemical Development: Employed in the synthesis of advanced, fluorinated pesticide and herbicide molecules to enhance efficacy and environmental profile.
• Ligand and Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology & Probe Development: Useful for incorporating fluorinated phenyl groups into molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-(4-Fluorophenyl)Carbonylethylboronic Acid Pinacol Ester
CAS No.	1648906-43-7
Molecular Formula	C15H20BFO3
Molecular Weight	278.13 g/mol
Synonyms	2-(4-Fluorobenzoyl)ethylboronic Acid Pinacol Ester; (2-(4-Fluorobenzoyl)ethyl)boronic Acid Pinacol Ester; 4-Fluoro-β-oxo-benzenepropaneboronic Acid Pinacol Ester; 1-(4-Fluorophenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-fluorophenyl)propan-1-one; Pinacol [2-(4-Fluorobenzoyl)ethyl]boronate
EINECS	Contact for details

Quality Control

Our 2-(4-Fluorophenyl)Carbonylethylboronic Acid Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for critical R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to in-house specifications aligned with ICH guidelines for impurities, ensuring the material is suitable for use in pharmaceutical development under GMP-like conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.