Description

1-Methyl-4-{1-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropyl}Piperazine is a sophisticated boronic ester derivative, a critical intermediate in modern pharmaceutical and agrochemical research. Its value lies in its role as a key building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for medicinal chemists and process development scientists in pharmaceutical R&D, agrochemical discovery, and advanced materials science.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling methodologies.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for target identification and validation studies.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale manufacturing of complex organic molecules.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in synthetic methodology development and library synthesis.

Basic Information

Product Name	1-Methyl-4-{1-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropyl}Piperazine
CAS No.	1643923-77-6
Molecular Formula	C19H29BN2O2
Molecular Weight	328.26 g/mol
Synonyms	1-Methyl-4-[1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]piperazine; 4-[1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]-1-methylpiperazine; 1-Methyl-4-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)piperazine; Pinacol [1-(4-(4-Methylpiperazin-1-yl)cyclopropyl)phenyl]boronate; [1-(4-(4-Methylpiperazin-1-yl)cyclopropyl)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-{1-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropyl}Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.