Description

Rel-(1S,4S)-4-Hydroxy-4-(Trifluoromethyl)Cyclohexane-1-Carboxylic Acid is a high-value, chiral trifluoromethylated cyclohexane derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique stereochemistry and the presence of both hydroxyl and carboxylic acid functional groups make it a versatile building block for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its trifluoromethyl group can significantly enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology, central nervous system (CNS), and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its rigid cyclohexane core and functional groups can modify material properties.
• Chemical Biology Probes: Utilized as a building block for labeled compounds and molecular probes in drug discovery and mechanistic studies.

Basic Information

Product Name	Rel-(1S,4S)-4-Hydroxy-4-(Trifluoromethyl)Cyclohexane-1-Carboxylic Acid
CAS No.	1643570-58-4
Molecular Formula	C8H11F3O3
Molecular Weight	212.17 g/mol
Synonyms	4-Hydroxy-4-(trifluoromethyl)cyclohexanecarboxylic acid (rel-(1S,4S)-isomer); (1S,4S)-4-Hydroxy-4-(trifluoromethyl)cyclohexane-1-carboxylic acid; rel-(1S,4S)-4-(Trifluoromethyl)-4-hydroxycyclohexanecarboxylic acid; 4-Hydroxy-4-trifluoromethyl-cyclohexanecarboxylic acid; 4-(Trifluoromethyl)-4-hydroxycyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 4-hydroxy-4-(trifluoromethyl)-, (1S,4S)-rel-; CAS 1643570-58-4
EINECS	Contact for details

Quality Control

Our Rel-(1S,4S)-4-Hydroxy-4-(Trifluoromethyl)Cyclohexane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure consistent identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.