Description

Boronic Acid, B-(3-Chloro-4,5-Difluorophenyl)- is a high-purity, halogenated arylboronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries seeking to synthesize complex, fluorinated molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the chloro-difluorophenyl moiety imparts desired biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic semiconductors for OLEDs and electronic devices.
• Chemical Biology & Proteomics: Employed in the design of molecular probes, enzyme inhibitors, and bioconjugation reagents leveraging boronic acid's affinity for diols.
• Academic & Contract Research: A valuable reagent for methodological development in cross-coupling catalysis and the exploration of new chemical space in medicinal chemistry programs.
• Scale-up Process Development: Suitable for optimization and kilogram-scale production under GMP or non-GMP conditions for clinical trial material synthesis.

Basic Information

Product Name	Boronic Acid, B-(3-Chloro-4,5-Difluorophenyl)-
CAS No.	1643467-84-8
Molecular Formula	C6H4BClF2O2
Molecular Weight	191.36 g/mol
Synonyms	(3-Chloro-4,5-difluorophenyl)boronic acid; 3-Chloro-4,5-difluorobenzeneboronic acid; B-(3-Chloro-4,5-difluorophenyl)boronic acid; (3-Chloro-4,5-difluoro-phenyl)boronic acid; 3-Chloro-4,5-difluorophenyl-Boronic Acid; Boronic acid, B-(3-chloro-4,5-difluorophenyl)-; 1643467-84-8
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-(3-Chloro-4,5-Difluorophenyl)- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom specifications can be developed to support your specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.