Description

Bocnh-Peg12-Ch2Ch2Nh2 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected amine on one terminus and a primary amine on the other. This compound is engineered to facilitate the controlled conjugation of biomolecules, peptides, and small molecules, enabling precise spacing and solubility enhancement. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science, where reliable, high-purity linkers are essential for creating next-generation therapeutics and diagnostics.

Application

• Bioconjugation and ADC Development: Used as a heterobifunctional crosslinker for attaching cytotoxic drugs, fluorophores, or targeting ligands to antibodies, proteins, or peptides in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• PEGylation Chemistry: Serves as a versatile building block for introducing PEG chains to improve the pharmacokinetic properties, solubility, and stability of therapeutic peptides and proteins.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a spacer or handle for the synthesis of complex, branched, or cyclic peptide constructs requiring orthogonal protection strategies.
• Polymer and Material Science: Acts as a functional monomer or initiator for creating amine-functionalized, PEG-based hydrogels, nanoparticles, and smart materials for drug delivery and tissue engineering.
• Diagnostic Reagent Formulation: Utilized in the development of diagnostic assays and imaging probes where controlled linkage between recognition elements and signal generators is required.
• Chemical Biology and Probe Design: Facilitates the creation of chemical probes for studying protein-protein interactions, cellular localization, and enzyme activity.

Basic Information

Product Name	Bocnh-Peg12-Ch2Ch2Nh2
CAS No.	1642551-09-4
Molecular Formula	C33H68N2O15
Molecular Weight	732.9 g/mol
Synonyms	1-tert-Butoxycarbonylamino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-48-amine; Boc-NH-PEG12-CH2CH2-NH2; tert-Butyl (2-(2-(2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate; Boc-Amine-PEG12-Amine; H2N-PEG12-NHBoc; Boc-NH-PEG12-C2-NH2; Boc-protected PEG diamine (PEG12 spacer); α-Boc-amino-ω-amino-dodecaethylene glycol
EINECS	Contact for details

Quality Control

Our Bocnh-Peg12-Ch2Ch2Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep containers tightly sealed in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.