Description

1,3,2-Dioxaborolane, 2-[3-(Difluoromethoxy)-5-Fluorophenyl]-4,4,5,5-Tetramethyl- is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, fluorinated molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex, fluorinated drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables efficient and selective carbon-carbon bond formation for constructing biaryl and heterobiaryl structures in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of advanced, fluorinated active ingredients for crop protection products with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or functionalization agent in the creation of novel organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Synthesis: Employed in academic and industrial R&D laboratories for method development and the synthesis of complex organic molecules for various applications.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3-(Difluoromethoxy)-5-Fluorophenyl]-4,4,5,5-Tetramethyl-
CAS No.	1641578-50-8
Molecular Formula	C₁₃H₁₆B₁F₃O₃
Molecular Weight	288.08 g/mol
Synonyms	2-(3-(Difluoromethoxy)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [3-(Difluoromethoxy)-5-fluorophenyl]boronic acid pinacol ester; 3-(Difluoromethoxy)-5-fluorophenylboronic acid pinacol ester; (3-(Difluoromethoxy)-5-fluorophenyl)pinacolboronate; 5-Fluoro-3-(difluoromethoxy)phenylboronic acid pinacol ester; Pinacol [3-(difluoromethoxy)-5-fluorophenyl]boronate; CAS 1641578-50-8
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-[3-(Difluoromethoxy)-5-Fluorophenyl]-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.