Description

(1S,2S)-2-{[(tert-Butoxy)Carbonyl]Amino}-1-Fluorocyclobutane-1-Carboxylic Acid is a high-purity, chiral fluorinated cyclobutane derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique stereochemistry and the presence of both a protected amine and a carboxylic acid functional group, enabling precise molecular construction. It is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including protease inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Protease Inhibitor Synthesis: Used in constructing core scaffolds for inhibitors targeting various viral and disease-related proteases.
• Peptidomimetics Development: Incorporates fluorinated cyclobutane motifs to enhance metabolic stability and binding affinity in peptide-based drug design.
• Agrochemical Active Ingredient R&D: Serves as a building block for novel herbicides, fungicides, or insecticides with improved properties.
• Chemical Biology Probes: Utilized in creating labeled or modified compounds for studying enzyme mechanisms and biological pathways.
• Material Science Research: Potential precursor for specialty polymers or liquid crystals where fluorinated, rigid structures are beneficial.

Basic Information

Product Name	(1S,2S)-2-{[(tert-Butoxy)Carbonyl]Amino}-1-Fluorocyclobutane-1-Carboxylic Acid
CAS No.	1639454-85-5
Molecular Formula	C11H18FNO4
Molecular Weight	247.26 g/mol
Synonyms	(1S,2S)-1-Fluoro-2-[(tert-butoxycarbonyl)amino]cyclobutane-1-carboxylic acid; (1S,2S)-2-((tert-Butoxycarbonyl)amino)-1-fluorocyclobutane-1-carboxylic acid; (1S,2S)-2-(Boc-amino)-1-fluorocyclobutane-1-carboxylic acid; Boc-(1S,2S)-AFC-OH; (1S,2S)-1-Fluoro-2-[(Boc)amino]cyclobutane-1-carboxylic acid; tert-Butyl ((1S,2S)-1-fluoro-3-carboxycyclobutyl)carbamate; (1S,2S)-2-Amino-1-fluorocyclobutane-1-carboxylic acid Boc derivative
EINECS	Contact for details

Quality Control

Every batch of (1S,2S)-2-{[(tert-Butoxy)Carbonyl]Amino}-1-Fluorocyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.