Description

2-(5-Chloro-2-Fluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients, such as kinase inhibitors and novel crop protection agents. The compound, CAS NO 1638847-73-0, is supplied with stringent quality control to ensure optimal performance in sensitive applications.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the introduction of the chlorophenyl moiety is critical for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the synthesis of molecular probes for target identification and validation.
• Catalyst Ligand Development: Acts as a starting material for synthesizing sophisticated bidentate or monodentate ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex, high-value molecules under cGMP conditions.

Basic Information

Product Name	2-(5-Chloro-2-Fluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1638847-73-0
Molecular Formula	C₁₃H₁₇BClFO₂
Molecular Weight	285.53 g/mol
Synonyms	5-Chloro-2-fluoro-3-methylbenzeneboronic acid pinacol ester; (5-Chloro-2-fluoro-3-methylphenyl)boronic acid pinacol ester; 2-Fluoro-5-chloro-3-methylbenzeneboronic acid pinacol ester; Pinacol (5-chloro-2-fluoro-3-methylphenyl)boronate; B-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1638847-73-0; Boronic acid, B-(5-chloro-2-fluoro-3-methylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Chloro-2-Fluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and tested under a rigorous quality management system. We provide comprehensive analytical data, including HPLC purity, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and mass spectrometry to confirm identity and potency. A Certificate of Analysis (COA) is supplied with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we support development under ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) after opening. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.