Description

tert-Butyl 6-Oxo-8-Azabicyclo[3.2.1]Octane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected bicyclic amino esters. This compound is a critical building block in modern organic synthesis, valued for its rigid, three-dimensional scaffold which is essential for constructing complex molecular architectures with high stereochemical control. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries of novel compounds in drug discovery and lead optimization programs.
• Process Chemistry Development: Used in the scale-up and route scouting for the commercial manufacturing of APIs, where its protected amine functionality is crucial.
• Asymmetric Synthesis: The bicyclic structure acts as a chiral template or auxiliary for the synthesis of enantiomerically pure compounds.
• Academic & Industrial R&D: Employed in methodological studies and the development of new synthetic transformations involving strained ring systems.

Basic Information

Product Name	tert-Butyl 6-Oxo-8-Azabicyclo[3.2.1]Octane-8-Carboxylate
CAS No.	1638772-07-2
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	8-Boc-8-azabicyclo[3.2.1]octan-6-one; tert-Butyl 6-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate; 8-Azabicyclo[3.2.1]octan-6-one, 8-(1,1-dimethylethoxy)carbonyl]-; 8-(tert-Butoxycarbonyl)-8-azabicyclo[3.2.1]octan-6-one; BOC-8-Azabicyclo[3.2.1]octan-6-one; 8-Boc-8-aza-bicyclo[3.2.1]octan-6-one; 1638772-07-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Oxo-8-Azabicyclo[3.2.1]Octane-8-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and production. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as confirmed by HPLC, GC, NMR, and MS. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.