Description

(2R)-2-(Fluoromethyl)Azetidine Hcl is a high-purity, chiral azetidine derivative hydrochloride salt, serving as a critical building block in modern synthetic chemistry. Its value lies in its unique fluorinated azetidine scaffold, which is increasingly sought after for modulating the physicochemical and metabolic properties of bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluoromethyl group can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioisosteres: The azetidine ring acts as a constrained bioisostere for peptide bonds or other heterocycles in medicinal chemistry programs.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers with unique properties.

Basic Information

Product Name	(2R)-2-(Fluoromethyl)Azetidine Hcl
CAS No.	1638764-65-4
Molecular Formula	C4H9ClFN
Molecular Weight	137.57 g/mol
Synonyms	(2R)-2-(Fluoromethyl)azetidine hydrochloride; (R)-2-(Fluoromethyl)azetidine HCl; Azetidine, 2-(fluoromethyl)-, hydrochloride, (2R)-; (2R)-2-(Fluoromethyl)azetidine monohydrochloride; (R)-2-(Fluoromethyl)azetidine hydrochloride; (2R)-2-(Fluoromethyl)-azetidine HCl; 1638764-65-4; (R)-2-(Fluoromethyl)azetidine HCl salt
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-(Fluoromethyl)Azetidine Hcl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with specifications tailored to meet the demanding requirements of process chemistry and early-stage pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.