Description

cis-4-Fluoro-3-Methoxypyrrolidine Hydrochloride is a high-purity, fluorinated pyrrolidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the unique combination of a fluorine atom and a methoxy group on the pyrrolidine ring, which is instrumental for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, crucial for creating enantiomerically pure compounds.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or a tagging reagent in probe development for studying biological systems.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers with tailored properties.

Basic Information

Product Name	cis-4-Fluoro-3-Methoxypyrrolidine Hydrochloride
CAS No.	1638761-46-2
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol
Synonyms	(3R,4S)-4-Fluoro-3-methoxypyrrolidine hydrochloride; (3S,4R)-4-Fluoro-3-methoxypyrrolidine hydrochloride; 4-Fluoro-3-methoxy-pyrrolidine HCl; 3-Methoxy-4-fluoropyrrolidine hydrochloride; Pyrrolidine, 4-fluoro-3-methoxy-, hydrochloride, cis-; 1638761-46-2; FC1(OC)C[C@@H]1N.ClH; FC1(OC)C[C@H]1N.ClH
EINECS	Contact for details

Quality Control

Our cis-4-Fluoro-3-Methoxypyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing purity, chiral excess, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.