Description

4-Cyano-1-Methyl-1H-Pyrazole-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and key building block for Suzuki-Miyaura cross-coupling reactions. Its value lies in enabling the efficient synthesis of complex heterocyclic compounds, which are crucial scaffolds in modern drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and antiviral research.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to construct complex biaryl and heteroaryl structures central to medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with pyrazole cores.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	4-Cyano-1-Methyl-1H-Pyrazole-5-Boronic Acid Pinacol Ester
CAS No.	1638360-07-2
Molecular Formula	C12H16BN3O2
Molecular Weight	245.09 g/mol
Synonyms	1-Methyl-4-cyano-1H-pyrazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrazole-4-carbonitrile; 4-Cyano-1-methyl-1H-pyrazole-5-boronic acid, pinacol ester; 1-Methyl-4-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 5-Borono-4-cyano-1-methyl-1H-pyrazole pinacol ester; 1638360-07-2; Pyrazole-5-boronic acid pinacol ester, 4-cyano-1-methyl-
EINECS	Contact for details

Quality Control

Our 4-Cyano-1-Methyl-1H-Pyrazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.