Description

Methyl4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-3-Carboxylate is a high-value organoboron building block, specifically a thiophene boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for the development of novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiophene heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Organic Electronics: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Material Science Research: Employed in the creation of novel organic frameworks, liquid crystals, and other functional materials.
• Chemical Synthesis: A versatile reagent for palladium-catalyzed cross-coupling reactions to create complex biaryl and heterobiaryl structures.
• Academic & R&D: Fundamental research tool in university and industrial laboratories for methodology development and exploring new chemical space.

Basic Information

Product Name	Methyl4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-3-Carboxylate
CAS No.	1637301-55-3
Molecular Formula	C13H19BO4S
Molecular Weight	282.16 g/mol
Synonyms	Methyl 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate; 3-Thiophenecarboxylic acid, 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate; 5-Boronic acid, 4-methyl-3-thiophenecarboxylic acid methyl ester, pinacol ester; Thiophene-3-carboxylic acid boronic ester derivative; Pinacol boronate ester of methyl 5-bromo-4-methylthiophene-3-carboxylate (common precursor); Borylation product of methyl thiophenecarboxylate.
EINECS	Contact for details

Quality Control

Our Methyl4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for extended shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.