Description

cis-tert-Butyl 3-(4-Fluorobenzoyl)Cyclobutylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker and warhead components for novel targeted protein degradation therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds under cGMP conditions.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	cis-tert-Butyl 3-(4-Fluorobenzoyl)Cyclobutylcarbamate
CAS No.	1630907-38-8
Molecular Formula	C16H20FNO3
Molecular Weight	293.34 g/mol
Synonyms	tert-Butyl N-[cis-3-(4-fluorobenzoyl)cyclobutyl]carbamate; 1,1-Dimethylethyl N-[cis-3-(4-fluorobenzoyl)cyclobutyl]carbamate; cis-3-[(tert-Butoxycarbonyl)amino]cyclobutyl(4-fluorophenyl)methanone; BOC-protected 3-(4-Fluorobenzoyl)Cyclobutylamine (cis isomer); (cis)-3-((tert-Butoxycarbonyl)amino)cyclobutyl(4-fluorophenyl)methanone; 1630907-38-8; cis-Boc-3-(4-Fluorobenzoyl)Cyclobutylamine
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl 3-(4-Fluorobenzoyl)Cyclobutylcarbamate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.