Description

trans-tert-Butyl 3-(4-Fluorobenzoyl)Cyclobutylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutyl carbamate scaffold with a fluorinated benzoyl moiety. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing active pharmaceutical ingredients (APIs) for oncology, CNS disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting protein-protein interactions or kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or ligands in bifunctional degrader molecules.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation in cellular assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	trans-tert-Butyl 3-(4-Fluorobenzoyl)Cyclobutylcarbamate
CAS No.	1630906-41-0
Molecular Formula	C16H20FNO3
Molecular Weight	293.34 g/mol
Synonyms	trans-1-N-Boc-3-(4-fluorobenzoyl)cyclobutanamine; tert-Butyl N-[trans-3-(4-fluorobenzoyl)cyclobutyl]carbamate; 3-(4-Fluorobenzoyl)cyclobutanamine, N-Boc-trans-; trans-3-(4-Fluorobenzoyl)cyclobutanamine 1-carboxylic acid tert-butyl ester; BOC-trans-3-(4-Fluorobenzoyl)cyclobutanamine; 1-Boc-trans-3-(4-fluorobenzoyl)cyclobutanamine; (trans)-tert-Butyl (3-(4-fluorobenzoyl)cyclobutyl)carbamate
EINECS	Contact for details

Quality Control

Our trans-tert-Butyl 3-(4-Fluorobenzoyl)Cyclobutylcarbamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.