Description

3-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a versatile boronic ester pinacol group. This compound is a critical building block in modern organic synthesis, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aromatic rings, essential for synthesizing biaryl structures found in many drug candidates.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated benzonitrile core.
• Chemical Biology & Probe Development: Useful for creating molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific, functionalized aromatic systems.

Basic Information

Product Name	3-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1630082-46-0
Molecular Formula	C16H20BNO2
Molecular Weight	269.15 g/mol
Synonyms	4-Cyano-2-cyclopropylphenylboronic acid pinacol ester; 2-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 3-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; (4-Cyano-2-cyclopropylphenyl)boronic acid pinacol ester; 2-Cyclopropyl-4-(pinacolboryl)benzonitrile; B-(4-Cyano-2-cyclopropylphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Cyclopropyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged procedures to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.