Description

2-Fluoro-4-Methyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzoic Acid Methyl Ester is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex fluorinated and methylated aromatic systems. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise molecular architecture for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic rings for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and boronic ester functional groups for targeted activity.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs) with tailored properties.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and bioconjugation reagents for diagnostic and biochemical research applications.
• Custom Synthesis & Contract Manufacturing: An ideal starting material for custom synthesis projects requiring specific, complex fluorinated biphenyl or heterobiaryl structures.

Basic Information

Product Name	2-Fluoro-4-Methyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzoic Acid Methyl Ester
CAS No.	1629913-80-9
Molecular Formula	C15H20BFO4
Molecular Weight	294.13 g/mol
Synonyms	Methyl 2-Fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 2-Fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; 5-Boronic acid, 2-fluoro-4-methyl-, 1,3,2-dioxaborolane ester, methyl benzoate derivative; Pinacol 2-Fluoro-4-methyl-5-(methoxycarbonyl)phenylboronate; (2-Fluoro-4-methyl-5-(methoxycarbonyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 2-Fluoro-4-Methyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F, 11B), and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available for every shipment, ensuring traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.