Description

6-(3,5-Dimethylisoxazol-4-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One (Wxg03036) is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is essential for modern medicinal chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex, biologically active molecules. It is primarily sought by R&D and production teams in the pharmaceutical and biotechnology sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for creating carbon-carbon bonds under mild conditions, a cornerstone of modern synthetic chemistry.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of heterobifunctional molecules designed for targeted protein degradation.
• Kinase Inhibitor Synthesis: A key precursor in the manufacturing of small-molecule kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes to study biological pathways and protein function.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development pipelines.

Basic Information

Product Name	6-(3,5-Dimethylisoxazol-4-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One (Wxg03036)
CAS No.	1629614-14-7
Molecular Formula	C₁₈H₂₄BN₃O₄
Molecular Weight	357.21 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(3,5-dimethylisoxazol-4-yl)-1,3-dihydro-2H-benzimidazol-2-one; 6-(3,5-Dimethyl-4-isoxazolyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2(3H)-one; WXG03036; WXG-03036; 1629614-14-7; Benzimidazolone boronic ester pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-1,3-benzodiazol-2-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Every lot is analyzed using advanced techniques like HPLC, NMR, and LC-MS to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.