Description

1,3-Benzodioxole, 5-Chloro-2,2-Difluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound matters as a critical building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing the benzodioxole scaffold.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron-containing coupling partner for the formation of carbon-carbon bonds, essential for creating complex organic architectures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Useful for synthesizing tagged molecules for studying biological pathways and target engagement.
• Ligand and Catalyst Development: Acts as a starting material for creating novel ligands and catalysts used in asymmetric synthesis.

Basic Information

Product Name	1,3-Benzodioxole, 5-Chloro-2,2-Difluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1628572-71-3
Molecular Formula	C₁₅H₁₈BClF₂O₄
Molecular Weight	342.56 g/mol
Synonyms	5-Chloro-2,2-difluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole; 2-(5-Chloro-2,2-difluorobenzo[d][1,3]dioxol-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2,2-difluorobenzo[d][1,3]dioxole-6-boronic acid pinacol ester; (5-Chloro-2,2-difluorobenzo[d][1,3]dioxol-6-yl)boronic acid pinacol ester; CAS 1628572-71-3
EINECS	Contact for details

Quality Control

Our 1,3-Benzodioxole, 5-Chloro-2,2-Difluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.