Description

3-Acetamidobicyclo[1.1.1]pentan-1-yl acetate is a high-purity, advanced pharmaceutical intermediate featuring the unique and highly sought-after bicyclo[1.1.1]pentane (BCP) scaffold. This compound matters for its role in modern drug discovery, where the BCP unit is valued as a bioisostere for *para*-substituted benzene rings or tert-butyl groups, offering improved metabolic stability, solubility, and physicochemical properties to novel therapeutic candidates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for synthesizing next-generation small molecule drugs targeting CNS disorders, inflammatory diseases, and oncology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) incorporating the bicyclo[1.1.1]pentane pharmacophore.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug-like properties of candidate molecules.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead sections of bifunctional degraders due to its rigid, three-dimensional structure.
• CNS Drug Research: Applied in the development of central nervous system therapeutics where the BCP motif can enhance blood-brain barrier penetration.
• Agrochemical Research: Potential intermediate for creating novel crop protection agents with enhanced stability and efficacy.
• Material Science Exploration: Investigated as a monomer or cross-linker for creating polymers with unique thermal and mechanical properties.

Basic Information

Item	Details
Product Name	3-Acetamidobicyclo[1.1.1]pentan-1-yl acetate
CAS No.	1628196-23-5
Molecular Formula	C9H13NO3
Molecular Weight	183.20 g/mol
Synonyms	1-Acetoxy-3-acetamidobicyclo[1.1.1]pentane; 3-Acetamido-1-acetoxybicyclo[1.1.1]pentane; BCP Acetate Acetamide Derivative; 3-Acetamidobicyclo[1.1.1]pentan-1-ol acetate; 1-Acetoxy-3-(acetylamino)bicyclo[1.1.1]pentane; (3-Acetamidobicyclo[1.1.1]pentan-1-yl) acetate
EINECS	Contact for details

Quality Control

Our 3-Acetamidobicyclo[1.1.1]pentan-1-yl acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full specification data are provided for each lot to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.