Description

4-(tert-Butylaminomethyl)Benzeneboronic Acid Pinacol Ester is a high-value, organoboron building block characterized by its protected boronic acid functionality and a tertiary amine-substituted benzyl group. This compound matters for its dual reactivity, serving as a key intermediate in sophisticated cross-coupling reactions like the Suzuki-Miyaura coupling, while its amine moiety offers a handle for further functionalization. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its structural features for bioactivity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for forming carbon-carbon bonds with aryl/vinyl halides, enabling the construction of biaryl and other conjugated systems.
• Ligand and Catalyst Development: The tert-butylaminomethyl group can be utilized to create novel chelating ligands for transition metal catalysis.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	4-(tert-Butylaminomethyl)Benzeneboronic Acid Pinacol Ester
CAS No.	1628014-71-0
Molecular Formula	C₁₇H₂₈BNO₂
Molecular Weight	289.22 g/mol
Synonyms	4-[(tert-Butylamino)methyl]benzeneboronic acid pinacol ester; 4-(N-tert-Butylaminomethyl)phenylboronic acid pinacol ester; [4-[(tert-Butylamino)methyl]phenyl]boronic acid pinacol ester; 4-(tert-Butylaminomethyl)phenylboronic acid pinacol ester; B-[4-[(1,1-Dimethylethyl)amino]methyl]phenyl]-5,5-dimethyl-2-oxa-1,3,2-dioxaborinane; (4-((tert-Butylamino)methyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(tert-Butylaminomethyl)Benzeneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR (¹H, ¹³C, ¹¹B) for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.